Lepra reactions (LR) are acute inflammatory conditions with immune mediators that are highly morbid. Patients with the lepromatous end of the leprosy spectrum (BL-LL) are the only ones who develop Type-2 LR. 90% of the time, it happens during or right after treatment, usually within 2 years. The emergence of Erythema Nodosum Leprosum (ENL) suggests a paradoxical immune reaction and hypersensitivity to leprosy bacteria that results in painful erythematous nodules and systemic symptoms. Here, we present a case of Type 2 LR in a 41-year-old Indian man diagnosed with lepromatous leprosy 2 years ago. He was treated with MDT regime for 12 months and was compliant with treatment till 1 month before presenting with fever, cough, red eyes, and painful erythematous nodules involving his trunk and extremities. This case underscores the severe systemic inflammatory response that can be triggered by noncompliance with MDT, mimicking sepsis and requiring prompt recognition and management. Early recognition of ENL and appropriate management are essential to alleviate symptoms and prevent serious complications that may result from this serious condition.
BT - Case reports in infectious diseases C1 -https://www.ncbi.nlm.nih.gov/pubmed/41132236
DA - 10/2025 DO - 10.1155/crdi/1071013 J2 - Case Rep Infect Dis LA - eng M3 - Case Report N2 -Lepra reactions (LR) are acute inflammatory conditions with immune mediators that are highly morbid. Patients with the lepromatous end of the leprosy spectrum (BL-LL) are the only ones who develop Type-2 LR. 90% of the time, it happens during or right after treatment, usually within 2 years. The emergence of Erythema Nodosum Leprosum (ENL) suggests a paradoxical immune reaction and hypersensitivity to leprosy bacteria that results in painful erythematous nodules and systemic symptoms. Here, we present a case of Type 2 LR in a 41-year-old Indian man diagnosed with lepromatous leprosy 2 years ago. He was treated with MDT regime for 12 months and was compliant with treatment till 1 month before presenting with fever, cough, red eyes, and painful erythematous nodules involving his trunk and extremities. This case underscores the severe systemic inflammatory response that can be triggered by noncompliance with MDT, mimicking sepsis and requiring prompt recognition and management. Early recognition of ENL and appropriate management are essential to alleviate symptoms and prevent serious complications that may result from this serious condition.
PY - 2025 SP - 1 EP - 5 T2 - Case reports in infectious diseases TI - Revealing Erythema Nodosum Leprosum in a Leprosy Patient: A Case of Treatment Noncompliance. UR - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/crdi/1071013?download=true VL - 2025 SN - 2090-6625 ER -