Histoid leprosy (HL) is a very rare and highly infectious variant of lepromatous leprosy, presenting as skin-coloured, succulent nodules and plaques on apparently healthy skin. It is histologically characterized by a dense bundle of histiocytes arranged in storiform manner. Usually, it occurs in patients with leprosy who relapse after dapsone monotherapy or inadequate antileprotic treatment; it can even arise de novo. We present a case of umbilicated presentation in a patient with a case of relapse HL, even after adequate treatment with multibacillary multidrug therapy for 12 months. Although rare, the higher load of lepra bacilli in these cases makes it a matter of concern, and challenging for leprologists to make early diagnosis and treatment.
BT - Skin Health and Disease DO - 10.1093/skinhd/vzaf067 LA - ENG M3 - Case Report N2 -Histoid leprosy (HL) is a very rare and highly infectious variant of lepromatous leprosy, presenting as skin-coloured, succulent nodules and plaques on apparently healthy skin. It is histologically characterized by a dense bundle of histiocytes arranged in storiform manner. Usually, it occurs in patients with leprosy who relapse after dapsone monotherapy or inadequate antileprotic treatment; it can even arise de novo. We present a case of umbilicated presentation in a patient with a case of relapse HL, even after adequate treatment with multibacillary multidrug therapy for 12 months. Although rare, the higher load of lepra bacilli in these cases makes it a matter of concern, and challenging for leprologists to make early diagnosis and treatment.
PB - Oxford University Press (OUP) PY - 2025 SP - 1 EP - 3 T2 - Skin Health and Disease TI - An unusual presentation in relapse case of histoid leprosy UR - https://watermark02.silverchair.com/vzaf067.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA28wggNrBgkqhkiG9w0BBwagggNcMIIDWAIBADCCA1EGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM3R3GmvKZyyzrPvkFAgEQgIIDIpnSvG0pHIyHa_E2dI3Egjh9fQzFZxUaL8naV5z8q6rnp SN - 2690-442X ER -