TY - JOUR
KW - Cyclosporins
KW - Erythema Nodosum
KW - Humans
KW - Immune Tolerance
KW - In Vitro Techniques
KW - Lepromin
KW - leprosy
KW - Lymphocyte Activation
KW - Macrophages
KW - T-Lymphocytes, Regulatory
AU - Uyemura K
AU - Dixon J F
AU - Wong L
AU - Rea T H
AU - Modlin R L
AB - <p>Erythema nodosum leprosum (ENL) is a reactional state of lepromatous leprosy in which the loss of suppressor cell function, decrease in suppressor cell numbers, and increase of interleukin 2 production are observed. We reasoned that cyclosporine A (CsA), by opposing these immune responses, could suppress the ENL reaction and restore patients to the quiescent lepromatous state. We tested this hypothesis in vitro by measuring the effect of CsA on M. leprae-triggered suppressor cells. In 24 of 25 patients with ENL, suppressor cell activity was restored by CsA. The target of CsA appeared to be macrophages. These findings are significant in that they provide the first evidence for the potential efficacy of CsA in the treatment of ENL. Preliminary clinical trials indicate a beneficial therapeutic effect associated with increased T suppressor cells in lesions.</p>
BT - Journal of immunology (Baltimore, Md. : 1950)
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2946765?dopt=Abstract
DA - 1986 Dec 01
IS - 11
J2 - J. Immunol.
LA - eng
N2 - <p>Erythema nodosum leprosum (ENL) is a reactional state of lepromatous leprosy in which the loss of suppressor cell function, decrease in suppressor cell numbers, and increase of interleukin 2 production are observed. We reasoned that cyclosporine A (CsA), by opposing these immune responses, could suppress the ENL reaction and restore patients to the quiescent lepromatous state. We tested this hypothesis in vitro by measuring the effect of CsA on M. leprae-triggered suppressor cells. In 24 of 25 patients with ENL, suppressor cell activity was restored by CsA. The target of CsA appeared to be macrophages. These findings are significant in that they provide the first evidence for the potential efficacy of CsA in the treatment of ENL. Preliminary clinical trials indicate a beneficial therapeutic effect associated with increased T suppressor cells in lesions.</p>
PY - 1986
SP - 3620
EP - 3
T2 - Journal of immunology (Baltimore, Md. : 1950)
TI - Effect of cyclosporine A in erythema nodosum leprosum.
VL - 137
SN - 0022-1767
ER -