Leprosy is a rare and easily misdiagnosed infectious disease in China. Leprosy reactions (LRs) are the greatest challenge in the treatment of leprosy. If LRs cannot be identified early and treated in a timely manner, patients are at risk of developing disabilities. Type I reactions often occur in borderline leprosy, whereas type II reactions are more prevalent in lepromatous leprosy. Clinically, lepromatous leprosy with type I and II mixed LRs is less common. This report details a case of lepromatous leprosy with mixed LRs, where the patient sequentially developed type II and then type I reactions. Through 1 y of multidrug therapy and our timely identification and intervention for LRs during treatment, the patient achieved a successful cure without any sequelae.
BT - Transactions of The Royal Society of Tropical Medicine and Hygiene DO - 10.1093/trstmh/traf097 LA - ENG M3 - Case Report N2 -Leprosy is a rare and easily misdiagnosed infectious disease in China. Leprosy reactions (LRs) are the greatest challenge in the treatment of leprosy. If LRs cannot be identified early and treated in a timely manner, patients are at risk of developing disabilities. Type I reactions often occur in borderline leprosy, whereas type II reactions are more prevalent in lepromatous leprosy. Clinically, lepromatous leprosy with type I and II mixed LRs is less common. This report details a case of lepromatous leprosy with mixed LRs, where the patient sequentially developed type II and then type I reactions. Through 1 y of multidrug therapy and our timely identification and intervention for LRs during treatment, the patient achieved a successful cure without any sequelae.
PB - Oxford University Press (OUP) PY - 2025 T2 - Transactions of The Royal Society of Tropical Medicine and Hygiene TI - Unusual sequential type I and II reactions in lepromatous leprosy: a case report SN - 0035-9203, 1878-3503 ER -