Background
Mycobacterium lepra infection causes leprosy. Primarily affecting the skin and peripheral nerves, it is a persistent viral illness. Peripheral nerve damage can cause severe impairment and disability. The type of lipoproteins known as high-density lipoproteins (HDL) is distinguished by its capacity to return cholesterol from peripheral tissues to the liver. Their anti-inflammatory and antioxidant properties play a major part in their ability to prevent diseases. A pleiotropic molecule, interferon-gamma (IFN-γ) has mechanisms that are linked to antiproliferative, pro-apoptotic, and anticancer effects. Due to its ability to maintain both CD4+ and CD8+ cell activity and regulate a variety of protective functions, this effector cytokine is frequently regarded as a significant effector of immunity.
Aim
The current study aimed to evaluate HDL levels in sera of leprotic patients and assess its correlation with IFN-γ levels. Patients and methods This study included 31 leprotic patients and 30 healthy subjects as a control. Serum HDL is estimated by enzymatic methods using spectrophotometric assay kits while serum IFN-γ is estimated using commercially available enzyme-linked immunosorbent assay (ELISA).
Results
There was no statistically significant difference between the two studied groups regarding HDL. There was a higher statistically significant difference between the two studied groups regarding IFN-γ with higher levels in the cases group. There was no significant correlation between both HDL and IFN-γ and age and duration.
Conclusion
There is no correlation between serum levels of HDL and levels of IFN-γ in leprosy patients.
BT - Egyptian Journal of Dermatology and Venereology DO - 10.4103/ejdv.ejdv_63_24 IS - 3 LA - ENG M3 - Article N2 -Background
Mycobacterium lepra infection causes leprosy. Primarily affecting the skin and peripheral nerves, it is a persistent viral illness. Peripheral nerve damage can cause severe impairment and disability. The type of lipoproteins known as high-density lipoproteins (HDL) is distinguished by its capacity to return cholesterol from peripheral tissues to the liver. Their anti-inflammatory and antioxidant properties play a major part in their ability to prevent diseases. A pleiotropic molecule, interferon-gamma (IFN-γ) has mechanisms that are linked to antiproliferative, pro-apoptotic, and anticancer effects. Due to its ability to maintain both CD4+ and CD8+ cell activity and regulate a variety of protective functions, this effector cytokine is frequently regarded as a significant effector of immunity.
Aim
The current study aimed to evaluate HDL levels in sera of leprotic patients and assess its correlation with IFN-γ levels. Patients and methods This study included 31 leprotic patients and 30 healthy subjects as a control. Serum HDL is estimated by enzymatic methods using spectrophotometric assay kits while serum IFN-γ is estimated using commercially available enzyme-linked immunosorbent assay (ELISA).
Results
There was no statistically significant difference between the two studied groups regarding HDL. There was a higher statistically significant difference between the two studied groups regarding IFN-γ with higher levels in the cases group. There was no significant correlation between both HDL and IFN-γ and age and duration.
Conclusion
There is no correlation between serum levels of HDL and levels of IFN-γ in leprosy patients.
PB - Ovid Technologies (Wolters Kluwer Health) PY - 2025 SP - 293 EP - 300 T2 - Egyptian Journal of Dermatology and Venereology TI - High-density lipoprotein levels and its correlation with Interferon-gamma levels in leprosy patients UR - https://journals.lww.com/ejdv/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=01745968-202509000-00008 VL - 45 SN - 1110-6530 ER -