Diamino diphenyl sulfone (DDS), a chemotherapeutic compound used in the treatment of leprosy, was studied with regard to its effects on the embryonic development of eggs from the sea urchin Lytechinus variegatus. DDS disturbs the normal development of fertilized eggs by interfering with the mitotic apparatus and producing spheroid-shaped bodies shown to be aster-like bodies by staining techniques. A typical colchicine effect (formation of kidney-shaped cells) was also demonstrated.
BT - Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology C1 - http://www.ncbi.nlm.nih.gov/pubmed/2871992?dopt=Abstract DA - 1986 DO - 10.1016/0742-8413(86)90126-x IS - 2 J2 - Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. LA - eng N2 -Diamino diphenyl sulfone (DDS), a chemotherapeutic compound used in the treatment of leprosy, was studied with regard to its effects on the embryonic development of eggs from the sea urchin Lytechinus variegatus. DDS disturbs the normal development of fertilized eggs by interfering with the mitotic apparatus and producing spheroid-shaped bodies shown to be aster-like bodies by staining techniques. A typical colchicine effect (formation of kidney-shaped cells) was also demonstrated.
PY - 1986 SP - 295 EP - 306 T2 - Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology TI - The effect of diamino diphenyl sulfone on the embryonic development of eggs from the sea urchin (Lytechinus variegatus). VL - 83 SN - 0742-8413 ER -