Myelin changes were observed in fibres of nerves from cases of leprosy. The myelin had a 'loosened' appearance caused by increased and irregular separation of the intraperiod line. 'Loosening' might affect all, or only some, of the lamellae forming a myelin sheath. There was a patchy distribution of fibres with abnormal myelin, and they were seen only in nerves showing other marked pathological changes including the presence of oedema. The appearances are suggestive of intramyelinic oedema which may be related to the presence of endoneurial oedema.
BT - Acta neuropathologica C1 - http://www.ncbi.nlm.nih.gov/pubmed/2821728?dopt=Abstract DA - 1987 DO - 10.1007/bf00688341 IS - 1 J2 - Acta Neuropathol. LA - eng N2 -Myelin changes were observed in fibres of nerves from cases of leprosy. The myelin had a 'loosened' appearance caused by increased and irregular separation of the intraperiod line. 'Loosening' might affect all, or only some, of the lamellae forming a myelin sheath. There was a patchy distribution of fibres with abnormal myelin, and they were seen only in nerves showing other marked pathological changes including the presence of oedema. The appearances are suggestive of intramyelinic oedema which may be related to the presence of endoneurial oedema.
PY - 1987 SP - 75 EP - 80 T2 - Acta neuropathologica TI - Myelin changes in leprous neuropathy. VL - 74 SN - 0001-6322 ER -