TY - JOUR
KW - Antigens, Bacterial
KW - Cell Transformation, Viral
KW - Cells, Cultured
KW - Clone Cells
KW - Cytotoxicity, Immunologic
KW - Herpesvirus 4, Human
KW - Humans
KW - leprosy
KW - Lymphocyte Activation
KW - Mycobacterium
KW - Mycobacterium leprae
KW - Species Specificity
KW - T-Lymphocytes
AU - Launois P
AU - Shankar P
AU - Wallach D
AU - Flageul B
AU - Cottenot F
AU - Bach M A
AB - <p>T-cell clones capable of mounting a proliferative response to Mycobacterium leprae were obtained in three leprosy patients (two polar lepromatous and one polar tuberculoid) either from M. leprae-activated or from protein-purified derivative-activated polyclonal T lymphoblasts. All these clones expressed the CD4 surface marker. Some of them proliferated to the antigen only in the presence of interleukin-2. A majority expressed cross-reactive responses to other mycobacteria. Clones obtained from the lepromatous patients did not differ in any of these features from those obtained from the tuberculoid patient. M. leprae-reactive clones obtained from one lepromatous patient displayed strong antigen-specific cytotoxicity toward autologous antigen-coated target cells. This phenomenon was not observed for any clone of the other lepromatous patient and was seen only for one clone in the tuberculoid patient.</p>
BT - Annales de l'Institut Pasteur. Immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2830893?dopt=Abstract
DA - 1987 Sep-Oct
DO - 10.1016/s0769-2625(87)80027-2
IS - 5
J2 - Ann. Inst. Pasteur Immunol.
LA - eng
N2 - <p>T-cell clones capable of mounting a proliferative response to Mycobacterium leprae were obtained in three leprosy patients (two polar lepromatous and one polar tuberculoid) either from M. leprae-activated or from protein-purified derivative-activated polyclonal T lymphoblasts. All these clones expressed the CD4 surface marker. Some of them proliferated to the antigen only in the presence of interleukin-2. A majority expressed cross-reactive responses to other mycobacteria. Clones obtained from the lepromatous patients did not differ in any of these features from those obtained from the tuberculoid patient. M. leprae-reactive clones obtained from one lepromatous patient displayed strong antigen-specific cytotoxicity toward autologous antigen-coated target cells. This phenomenon was not observed for any clone of the other lepromatous patient and was seen only for one clone in the tuberculoid patient.</p>
PY - 1987
SP - 723
EP - 35
T2 - Annales de l'Institut Pasteur. Immunology
TI - Mycobacterium leprae-reactive T-cell clones isolated from polar lepromatous and tuberculoid leprosy patients.
VL - 138
SN - 0769-2625
ER -