TY - JOUR
KW - Complement Activating Enzymes
KW - Complement C1
KW - Complement C1q
KW - Complement C3
KW - Complement C3d
KW - Complement C4
KW - Complement Factor B
KW - Complement Pathway, Alternative
KW - Complement Pathway, Classical
KW - Complement System Proteins
KW - Erythema Nodosum
KW - Humans
KW - leprosy
KW - Leprosy, lepromatous
AU - Sehgal V N
AU - Sharma V
AU - Sharma V K
AB - <p>Complement components C1q and C4 of classic pathway; C3d, a breakdown product of C3, and factor B of alternate pathway: and C3, a component both of classic and alternate pathways, were studied in 35 patients, comprising 18 type I (Lepra) and 17 type II (ENL) reactions. There was a significant decrease in C3 and factor B with a concomitant rise of C3d during ENL. These changes indicate their preeminent role in immunogenesis of type II (ENL) reaction. The changes in the classic pathway components, on the other hand, were insignificant, apparently suggesting its limited involvement in ENL. Furthermore, reversion of factor B and C3d after subsidence of reaction is intriguing and may indicate that they are not substantially affected even with contemporary treatment. Complement components, of both classic and alternate pathways, showed no significant alterations either during type I (Lepra) reaction or after its amelioration.</p>
BT - International journal of dermatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2783924?dopt=Abstract
DA - 1989 Jan-Feb
DO - 10.1111/j.1365-4362.1989.tb01306.x
IS - 1
J2 - Int. J. Dermatol.
LA - eng
N2 - <p>Complement components C1q and C4 of classic pathway; C3d, a breakdown product of C3, and factor B of alternate pathway: and C3, a component both of classic and alternate pathways, were studied in 35 patients, comprising 18 type I (Lepra) and 17 type II (ENL) reactions. There was a significant decrease in C3 and factor B with a concomitant rise of C3d during ENL. These changes indicate their preeminent role in immunogenesis of type II (ENL) reaction. The changes in the classic pathway components, on the other hand, were insignificant, apparently suggesting its limited involvement in ENL. Furthermore, reversion of factor B and C3d after subsidence of reaction is intriguing and may indicate that they are not substantially affected even with contemporary treatment. Complement components, of both classic and alternate pathways, showed no significant alterations either during type I (Lepra) reaction or after its amelioration.</p>
PY - 1989
SP - 32
EP - 5
T2 - International journal of dermatology
TI - Comprehensive evaluation of complement components in the course of type I (Lepra) and type II (ENL) reactions.
VL - 28
SN - 0011-9059
ER -