01492nas a2200277   4500000000100000008004100001260001300042653001600055653001100071653001200082653001500094653002500109653000900134100001000143700001500153700001200168700001400180700001800194700001200212245005600224300001100280490000700291050003200298520087000330022001401200       1989                            d  c1989 Oct10aBone Marrow10aHumans10aleprosy10aLeukocytes10aMycobacterium leprae10aSkin1 aSen R1 aSehgal P K1 aSingh U1 aYadav M S1 aChaudhary S D1 aSikka R00aBacillaemia and bone marrow involvement in leprosy.  a445-520 v61  aInfolep Library - available3 a<p>Fifty patients (24 new and 26 receiving specific treatment) of leprosy were investigated to study the concentration and morphological index (MI) of the lepra bacilli in skin, peripheral blood and bone marrow. The organisms were detected in 28 cases on skin slit smear examination, in 38 cases on bone marrow examination and in 38 cases on examination of smears made from buffy coat of peripheral blood. Out of 22 cases negative for the bacilli on skin slit smears, 15 had the organisms either in buffy coat or bone marrow or both. Acid fast bacilli in peripheral blood and bone marrow with skin smear negativity were mainly observed in patients with paucibacillary type of the disease and in those who were receiving treatment. Examination of buffy coat and bone marrow for presence of lepra bacilli is suggested to establish the diagnosis in doubtful cases.</p>  a0254-9395