01829nas a2200289   4500000000100000008004100001260000900042653002000051653001400071653001100085653002500096653002500121653002000146653001600166653001600182653003900198653001800237653001800255100001200273700001800285700001600303245009400319300001000413490000600423520109600429022001401525       1989                            d  c198910aBrachial Plexus10aGranuloma10aHumans10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aLeukocyte Count10aLymphocytes10aMacrophages10aPeripheral Nervous System Diseases10aSkin Diseases10aT-Lymphocytes1 aKumar V1 aNarayanan R B1 aGirdhar B K00aComparison of the characteristics of infiltrates in skin and nerve granulomas of leprosy.  a19-240 v73 a<p>The characteristics of infiltrates in the dermal and neural granulomas from the same leprosy patients were compared by preparing a single cell suspension. Skin and nerve biopsies from 10 patients, 5 with tuberculoid and 5 with lepromatous leprosy were analysed. The granulomas contained lymphocytes and macrophages. Lymphocytes were the predominant infiltrating cells in the tuberculoid dermal and neural granulomas. A high proportion of lymphocytes in both the skin and nerve granulomas in these cases were activated T cells as they formed rosettes with sheep erythrocytes and expressed HLA-DR antigens. In contrast, lepromatous dermal and neural granulomas contained very few of these lymphocytes. Dermal and neural granulomas from both the types of leprosy contained mature macrophages as they were esterase positive, did not exhibit peroxidase activity and expressed HLA-DR antigens. These macrophages did not possess C3 surface receptors either. These findings suggest that the infiltrates in the skin and nerve granulomas of a given type of leprosy have similar characteristics.</p>  a0001-5938