02407nas a2200313   4500000000100000008004100001260001200042653002100054653003700075653002300112653002200135653002400157100001200181700001200193700001500205700001300220700001200233700001400245700001500259700001300274700001200287700001300299245004600312856009200358300000800450490000700458520161400465022001402079       2023                            d  c01/202310acytokine profile10aleprosy nerve conduction studies10aLeprosy neuropathy10aLeprosy reactions10apure neural leprosy1 aPitta I1 aAngst D1 aPinheiro R1 aVieira J1 aSpitz C1 aAndrade L1 aCarvalho L1 aHacker M1 aSarno E1 aJardim M00aCytokines profile in pure neural leprosy.  uhttps://www.frontiersin.org/articles/10.3389/fimmu.2023.1272471/pdf?isPublishedV2=False  a1-50 v143 a<p><strong>Introduction: </strong>Pure Neural Leprosy (PNL) is a form of this long time known disease that affects only the peripheral nervous system. Since it is a rare form of the disease, its pathophisiology is still poorly understood.</p>

<p><strong>Objective: </strong>Describe the cytokines profile in patients with PNL.</p>

<p><strong>Methods: </strong>30 Patients diagnosed with PNL in the Souza Araujo Outpatient Clinic and with cytokines evaluated were selected. They were evaluated by neurologists and diagnosed after a nerve biopsy. Serum levels of IL-1 β, IL-6, IL-10, IL-17, TNF, CCL-2/MCP-1, IFN-ϒ, CXCL-10/IP-10 and TGF-β were evaluates at the moment of the diagnosis.</p>

<p><strong>Results: </strong>Neural thickening was a common clinical finding in this groups of patients. Small and medium sensitive fibers signs and symptoms were present in 92% of the patients and motor involvement in 53%. 43% of patients presented neuropathic pain and no one had neuritis TGF-beta, IL-17, CCl-2 and IP-10. CCL-2 levels were associated with demyelinating patters and IP-10 and IL-1o were associated with axonal patterns at NCS.</p>

<p><strong>Discussion: </strong>PNL patients' cytokine profile appears to be different of other clinical forms of leprosy, with the presence of cytokines described in both tuberculoid and lepromatous leprosy. High levels of CCl-2 may be related to the presence of silent neuritis as well as the presence of IL-10. PNL is unique a form of leprosy, therefore, understanding its immunological profiles essential to better understand the disease itself.</p>
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