01344nas a2200301   4500000000100000008004100001260000900042653001800051653002000069653000800089653001400097653001100111653002500122653002500147653001200172653001600184653001600200653002500216653001800241653001400259100001800273700001600291245010600307300000900413490000600422520060000428022001401028       1989                            d  c198910aCell Division10aCells, Cultured10aDNA10aGranuloma10aHumans10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aLeucine10aLymphocytes10aMacrophages10aProtein Biosynthesis10aSkin Diseases10aThymidine1 aNarayanan R B1 aGirdhar B K00aIn vitro studies on dermal leprosy granulomas: assessment of division and protein synthesis of cells.  a13-70 v73 a<p>Single cell suspension from dermal leprosy granulomas (10 tuberculoid and 10 lepromatous) was prepared and an assessment of the division and protein synthesis by the cells was made. The cells of tuberculoid granulomas showed a high incorporation of 3H-thymidine and 14C-leucine. On the contrary, the cells of the lepromatous granulomas exhibited poor division but their protein synthesis remained unimpaired. These observations suggest that the epithelioid cell granuloma of tuberculoid leprosy appears to be more active and secretory than the macrophage granuloma of lepromatous leprosy.</p>  a0001-5938