01503nas a2200289   4500000000100000008004100001260001300042653001500055653001000070653001000080653002900090653003000119653001100149653001100160653002300171653001200194653000900206653001600215653001500231100001500246700002000261245005800281300000900339490000700348520084400355022001401199       1989                            d  c1989 Jan10aAdolescent10aAdult10aChild10aClinical Trials as Topic10aDrug Therapy, Combination10aFemale10aHumans10aLeprostatic Agents10aleprosy10aMale10aMiddle Aged10aRecurrence1 aPuavilai S1 aTimpatanapong P00aShort-course multi-drug therapy for leprosy patients.  a33-60 v723 a<p>Short-course multi-drug therapy for leprosy patients was evaluated in terms of effectiveness, recurrence rate and side effects. Of the 108 patients studied, 48.1 per cent defaulted. This MDT appeared to be quite effective in controlling leprosy. The medication could be stopped at 6 months in 83 per cent of the paucibacillary patients. The medication was continued further in 17 per cent of paucibacillary patients because of persistent skin lesions clinically and histopathologically. Recurrence occurred in 2.3 per cent of the paucibacillary patients. The effect of this regimen for multibacillary patient is difficult to evaluate because of the small number of patients studied. Side effects of this regimen occurred in 5.4 per cent of the patients. Leprosy reaction occurred in two patients with borderline lepromatous leprosy.</p>  a0125-2208