01336nas a2200289   4500000000100000008004100001260001600042653001200058653001500070653003100085653001600116653001200132653001100144653001000155653003600165653002400201653002500225653001200250653001100262100001300273700001800286245006700304300001000371490000900381520064200390022001401032       1989                            d  c1989 Apr 2610aAnimals10aArmadillos10aChromatography, Thin Layer10aGlycolipids10aleprosy10aLipids10aLiver10aMagnetic Resonance Spectroscopy10aMolecular Structure10aMycobacterium leprae10aPhenols10aSpleen1 aDaffé M1 aLanéelle M A00aDiglycosyl phenol phthiocerol diester of Mycobacterium leprae.  a333-70 v10023 a<p>A diglycosyl phenol phthiocerol diester that had not been previously detected was isolated from M. leprae-infected armadillo tissues. Spectroscopy methods allowed the elucidation of its structure. The diglycoside was a 2,3-di-O-methylrhamnopyranosyl (alpha 1----2)3-O-methylrhamnopyranosyl (alpha 1-linked to the phenolic hydroxyl of phthiocerol dimycocerosates). It differs from the major phenolic glycolipid (PGL I) only by the absence of the terminal 3,6-di-O-methylglucopyranosyl unit. The diglycoside could be an intermediate in the synthesis of the latter antigen or a degradative product in the host detoxification process.</p>  a0006-3002