01603nas a2200241   4500000000100000008004100001260003600042653001500078653002700093653001100120653002300131653002500154653002800179100001200207700001400219700001200233700001000245245007000255300001000325490000700335520100500342022001401347       2015                            d  bBentham Science Publishers Ltd.10aImmunology10aImmunology and Allergy10aAnergy10aleprosy immunology10acytokines in leprosy10aT cell unresponsiveness1 aSaini C1 aTarique M1 aKumar S1 aRao D00aRole of FoxP3+ Treg Cells Mediating Immune Suppression in Leprosy  a66-720 v113 a<p>Hansen’s disease commonly called leprosy is an infectious disease caused by M. leprae. Lepromatous leprosy is a generalized infection accompanied by T cell anergy towards M. leprae bugs with chronicity of lesions throughout the body [1]. The reason for unresponsiveness and T cells anergy against M. leprae antigens still remains a mystery. Recent studies have focused on regulatory T cells (Treg) as one of the foremen of all aspects of the immune response [2]. In this review, we have discussed the mechanism of Treg cells mediated immune suppression of M. leprae specific T cells and subsequently explained the epigenetic modification of FoxP3, which is the master regulator of Treg cells, during the course of progression from tuberculoid to lepromatous leprosy. This review aims at compiling and adding on to the knowledge about suppressor T cells mechanisms in leprosy, it also outlines an insight into manipulation of suppressor T cell function for overcoming disease manifestation.</p>
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