01699nas a2200265   4500000000100000008004100001260003800042653001300080653001200093653001500105653001800120653001400138653001400152653002100166653001700187653002000204653000900224100001400233700001600247700001200263245008100275300001000356520104900366020001801415       2023                            d  bSpringer International Publishing10aGenetics10aLeprosy10atratamento10aPolymorphisms10aCytokines10aAutophagy10aLipid Metabolism10aMitochondria10aTranscriptomics10aSNPs1 aMoraes MO1 aPinheiro RO1 aGeluk A00aMetabolic, Genetic and Immunological Mechanisms in Susceptibility to Leprosy  a71-793 a<p>In the past decade, the availability of data obtained from large-scale studies using molecular and genetic techniques has provided a much-improved picture of the main pathogenic pathways involved in the progression of leprosy. There is a clear clustering of genes encoding for hallmark immune response molecules, reinforcing the overall understanding of the immunopathogenic processes leading to leprosy susceptibility or to polarization between clinical phenotypes. Metabolic changes, cellular trafficking, and autophagy regulate the responses to confer protection and eliminate bacilli from the host. Alternatively, in hosts that are susceptible due to genetic and/or environmental conditions, immune cells fail to activate this protective program through the interference of&nbsp;<em>M. leprae</em>&nbsp;ultimately leading to disease development. Recent insights on the immunopathology of leprosy can pave the way for new diagnostics and personalized therapy based on the immune profile of the specific clinical form of the disease.</p>
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