01451nas a2200265   4500000000100000008004100001260003800042653001200080653001200092653001400104653001500118653001800133653001400151653001500165653002100180653001200201653000800213653001600221653001200237100001500249245007400264300000900338520082000347020001801167       2023                            d  bSpringer International Publishing10aHistory10aLeprosy10aM. leprae10aImmunology10amouse footpad10aArmadillo10aGlycolipid10aM. leprae genome10aDapsone10aMDT10aProphylaxis10aVaccine1 aScollard D00aThe Journey to a Scientific Understanding of Leprosy: A Brief Outline  a9-213 a<p>The many chapters in this textbook present medical and scientific knowledge about leprosy as we know it in 2022. That information is the result of numerous studies conducted in many countries. This chapter traces the major advances in understanding leprosy and how they developed, from the clinical definition in 1847, to the discovery of&nbsp;<em>M. leprae</em>&nbsp;in 1873, to the sequencing of&nbsp;<em>M. leprae</em>’s genome at the start of the twenty-first century. Landmark observations regarding the epidemiology and immunology of this disease are outlined, as well as the discovery of a cure and progress in treating its complications. Progress often closely follows technological developments, and the context of scientific and medical concepts surrounding each discovery is discussed briefly.</p>
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