01363nas a2200205   4500000000100000008004100001260003800042653003100080653002000111653002000131653002000151653002100171100001100192700001500203700001400218245003600232300001200268520085900280020001801139       2023                            d  bSpringer International Publishing10aLeprosy (Hansen's Disease)10aLepra reactions10aType 1 reaction10aType 2 reaction10aLucio Phenomenon1 aRao PN1 aSuneetha S1 aRathod SP00aReactions in Hansen’s Disease  a109-1313 a<p>Lepra reactions are acute exacerbations of disease occurring during the natural course of leprosy and can occur before, during, or after treatment. The immunopathogenesis of lepra reactions is still being elucidated. Reactions can affect the skin, nerves, eyes, and other internal organs. Reactions constitute the main event by which leprosy causes nerve damage and disability that is the reason for much of the fear and stigma associated with the disease. Early diagnosis and effective management of reactions is thus central to preventing disability. The early recognition of reactions demands clinical acumen, and their effective management requires careful judgement on the part of the healthcare provider. This chapter discusses lepra reactions, their clinical features, pathogenesis, histopathology, differential diagnosis, and management.</p>
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