01019nas a2200181   4500000000100000008004100001260003800042653002000080653001600100653001700116653001600133653001100149100001500160245008300175300001000258520055100268020001800819       2023                            d  bSpringer International Publishing10aPalaeopathology10aArchaeology10aBone Changes10aAncient DNA10aOrigin1 aRoberts CA00aThe Origin, Evolution and History of Leprosy Through a Palaeopathological Lens  a23-333 a<p>Leprosy has a long history as seen through historical evidence, and evidence in skeletons from archaeological sites that is several thousand years old. This section highlights the methods used to identify leprosy, reveals the bone changes of leprosy affecting the facial, hand and foot bones that are recognized by palaeopathologists, focuses on the global evidence for leprosy according to time and place, and shows how ancient DNA analysis of&nbsp;<em>M. leprae</em>&nbsp;is providing new insights on its origin, evolution and history.</p>
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