01253nas a2200265   4500000000100000008004100001260000900042653001200051653002300063653002800086653001100114653002300125653001300148653001200161653002600173653002500199653000900224100001700233700001500250245003400265300001000299490000700309520065700316022001400973       1989                            d  c198910aAnimals10aAntibody Formation10aArthritis, Experimental10aHumans10aImmunity, Cellular10aLepromin10aleprosy10aLymphocyte Activation10aMycobacterium leprae10aRats1 aBottasso O A1 aMorini J C00a[Immunopathology of leprosy].  a210-20 v493 a<p>Studies including close contacts of leprosy patients were performed; an inverse relationship between degree and length of exposure to Mycobacterium leprae (MI) and the magnitude of the in vivo specific immune response (Mitsuda reaction) was observed. On the other hand, this variable is greatly influenced by genetic determination. In the experimental adjuvant arthritis model, MI treatment was able to trigger a splenic suppressor cell population with regulatory activity on the immune response. These results suggest that the erythema nodosum leprosum episode (ENL) is related to an excessive humoral response and immunoregulatory alterations.</p>  a0025-7680