01466nas a2200289   4500000000100000008004100001260001300042653002900055653002700084653002800111653001100139653002000150653001200170653003400182653001300216100001400229700002300243700001500266700001400281700002000295700001800315245008600333300000900419490000700428520072700435022001401162       1989                            d  c1989 Jan10aAntigen-Antibody Complex10aChemical Precipitation10aEndocarditis, Bacterial10aHumans10aImmunodiffusion10aleprosy10aLupus Erythematosus, Systemic10aSyphilis1 aJayapal N1 aShanmugasundaram N1 aThomas P A1 aValli P R1 aThyagarajan S P1 aSubramanian S00aA simple method to quantitate circulating immune complexes in different diseases.  a33-90 v323 a<p>Immune Complexes are involved in the Pathogenesis of many diseases of varied aetiology such as autoimmune disorders, protozoal diseases, bacterial and viral infections. Quantitation of immune Complexes in these diseases can be used for diagnosis and to ascertain the prognosis. The simple method of precipitation by polyethylene glycol and quantitation by single Radial Immunodiffusion has been used in leprosy, syphilis, bacterial endocarditis and systemic lupus erythematosus (SLE). This method found significantly higher levels of circulating immune complexes (CICs) in erythema nodosum leprosum, culture positive bacterial endocarditis and SLE where CICs are known to play an important role in the pathogenesis.</p>  a0377-4929