01813nas a2200325   4500000000100000008004100001260001300042653001200055653002900067653001200096653003100108653002100139653002100160653001200181653000900193653002500202653003000227100001600257700001300273700001100286700001600297700001200313700001200325245010300337300000900440490000700449050003200456520098500488022001401473       1989                            d  c1989 Jan10aAnimals10aAntibody-Producing Cells10aDapsone10aHemolytic Plaque Technique10aImmunoglobulin G10aImmunoglobulin M10aleprosy10aMice10aMycobacterium leprae10aT-Lymphocytes, Regulatory1 aVaishnavi C1 aThakur M1 aKaur S1 aGanguly N K1 aNanda A1 aKumar B00aEffect of suppressor cells on antibody producing cells in mice infected with Mycobacterium leprae.  a72-80 v61  aInfolep Library - available3 a<p>Swiss albino mice were transfused with suppressor cells obtained after in vivo stimulation of mice with Con A (NS group). Some of the animals were infected with Mycobacterium leprae (NSI-group). Half of these animals were treated with dapsone (NSIT group). Adequate normal (NC) and infected (NI) controls were included. A plaque assay was carried out at different time periods to elucidate the effect of suppressor cells on antibody producing cells. No significant difference was seen in the number of plaque forming cells (PFC) in infected and dapsone treated animals (NSIT) when these were compared with controls. However significant increase seen in the number of IgM plaque forming cells at 6 months in NI and NSI groups and IgG PFC in NI group could be due to the peak footpad infection during this period. The significant decrease in the number of IgG PFC in NS and NSIT group compared to NC at 0 month is probably due to the suppressor cell activity in these groups.</p>  a0254-9395