02166nas a2200265   4500000000100000008004100001260003200042653002100074653002100095653002200116653001600138653000900154653002200163100001200185700001400197700002000211700001100231700001400242245010000256856008500356300001200441490000700453520141500460022002501875       2023                            d  bUniversitas Negeri Semarang10aGeneral Medicine10aLeprosy reaction10aReversal reaction10aC. ternatea10aIL-610aAnti-inflammatory1 aN. S NA1 aMuniroh M1 aKusumaningrum N1 aP M FE1 aYuniati R00aClitoria ternatea L. Extract as Adjuvant Therapy on Reducing IL–6 Levels in Reversal Reaction  uhttps://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/39808/14274  a105-1110 v153 a<p>Reversal reaction is a type IV cellular hypersensitivity reaction in leprosy. Interleukin-6 is a mediator with a pleiotropic effect on inflammation and immune response. Steroids are the standard therapy in the treatment of reaction reversal. Clitoria ternatea flower extract has anti-inflammatory properties. Long-term use of steroids can cause side effects. Therefore, it is necessary to give adjuvant therapy that can shorten the treatment period. This study aims to analyze the effect of adjuvant therapy of Clitoria ternatea extract to reduce IL-6 levels in reversal reaction. Experimental research design with pre and post-randomized single-blinded controlled trial, involving 22 subjects with reversal reaction. The control group received standard therapy and the treatment group received standard and adjuvant therapy with Clitoria ternatea extract. IL-6 levels were measured by ELISA. Data analysis used the Wilcoxon test and Independent T-test. The results showed a significant difference in treatment group (p=0.003) and control group (p=0.016). The mean decrease in serum IL-6 levels in treatment group was 81.35 pg/ml and in control group was 24.30 pg/ml (p=0.027). Clitoria ternatea showed a significant IL-6-lowering effect in patients with reversal reactions. This study has demonstrated the potential of Clitoria ternatea extract as adjuvant therapy in patients with leprosy reactions.</p>
  a2338-7610, 2085-191X