01409nas a2200253   4500000000100000008004100001260001700042653002400059653002400083653001700107653001100124653001200135653001800147653002500165653003100190653001800221653001700239100001400256245010900270300001100379490001500390520073600405022001401141       1989                            d  c1989 Mar-Apr10aAntigens, Bacterial10aGenes, MHC Class II10aHLA Antigens10aHumans10aleprosy10aMycobacterium10aMycobacterium leprae10aMycobacterium tuberculosis10aT-Lymphocytes10aTuberculosis1 aVries R R00aRegulation of T cell responsiveness against mycobacterial antigens by HLA class 2 immune response genes.  aS400-30 v11 Suppl 23 a<p>Helper T lymphocytes can only recognize mycobacterial antigens when they are presented by HLA class 2 molecules. Thus, these molecules may play an important role in the regulation of the immune response against mycobacteria. In this paper it is demonstrated that the T cells from individuals with different HLA class 2 molecules react to different mycobacterial antigens. These data indicate that HLA class 2 molecules are the products of immune response (Ir) genes for mycobacteria. Such genetically controlled differences in antimycobacterial T cell reactivity may explain the association of certain HLA class 2 alleles with a different course of mycobacterial infections and may have implications for vaccine development.</p>  a0162-0886