01564nas a2200253   4500000000100000008004100001260002400042653002400066653002700090653001700117100001500134700001700149700001500166700001600181700001800197700001400215700001800229245011700247856008000364300000800444490000700452520082600459022002501285       2023                            d  bFapUNIFESP (SciELO)10aInfectious Diseases10aMicrobiology (medical)10aParasitology1 aFinardi AJ1 aOliveira NGD1 aMoraes EBD1 aBatista LCF1 aBortolomai BE1 aSuffys PN1 aBaptista IMFD00aGenetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil  uhttps://www.scielo.br/j/rsbmt/a/46FySQyktbNVszSCzsnpWGS/?format=pdf&lang=en  a1-50 v563 a<p><strong>Background</strong>: Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006.</p>

<p><strong>Methods</strong>: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state.</p>

<p><strong>Results</strong>: The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity.</p>

<p><strong>Conclusions</strong>: A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented.</p>
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