00810nas a2200121   4500000000100000008004100001260003000042100001400072245008700086300001200173520048500185020001800670       2023                            d  bSpringer Nature Singapore1 aParija SC00aMycobacterium leprae, Mycobacterium lepraemurium and Non-tuberculosis Mycobacteria  a439-4563 a<p><em>Mycobacterium leprae</em>&nbsp;is the causative agent of leprosy, a chronic granulomatous disease primarily affecting the skin and peripheral nervous system.&nbsp;<em>M. leprae</em>&nbsp;was the first bacterial pathogen associated with a specific human disease and the only mycobacterium known to cause infection of the nervous tissue. The Koch postulates have never been fulfilled for&nbsp;<em>M. leprae</em>&nbsp;because so far, it has not been cultivated in vitro.</p>
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