02115nas a2200397   4500000000100000008004100001260001300042653002700055653002700082653002000109653002000129653001700149653001100166653002900177653003200206653001200238653002500250653002900275653001600304100001100320700001500331700001400346700001200360700001300372700001400385700001300399700001100412700001500423700001500438245009700453856004100550300001100591490000700602520109400609022001401703       1989                            d  c1989 Jun10aABO Blood-Group System10aDisease Susceptibility10aGenetic Linkage10aGenetic Markers10aHLA Antigens10aHumans10aImmunoglobulin Allotypes10aImmunoglobulin Gm Allotypes10aleprosy10aLeprosy, lepromatous10aRh-Hr Blood-Group System10aWest Indies1 aAbel L1 aDemenais F1 aBaule M S1 aBlanc M1 aMuller A1 aRaffoux C1 aMillan J1 aBois E1 aBabron M C1 aFeingold N00aGenetic susceptibility to leprosy on a Caribbean Island: linkage analysis with five markers.  uhttp://ila.ilsl.br/pdfs/v57n2a03.pdf  a465-710 v573 a<p>Our recent segregation analysis, carried out on 27 large pedigrees from a Caribbean island (Desirade), has shown the presence of recessive major gene(s) controlling susceptibility to leprosy per se and nonlepromatous leprosy, respectively. Linkage analysis was performed between each of these two detected genes and each of five markers typed in the Desirade population: HLA, ABO, Rhesus, Gm and Km. No positive significant lod score was observed. However, for leprosy per se close linkage was excluded with Rhesus and Gm (and also with ABO and HLA, considering a lower value for the frequency of the gene controlling susceptibility to leprosy per se). The highest lod score, although not significant, was obtained between the gene for nonlepromatous leprosy and ABO. Our overall results, joined with previous studies and experimental data, suggest that the gene controlling susceptibility to leprosy per se and that controlling susceptibility to nonlepromatous leprosy might be different, acting at successive stages of the immune response to infection with Mycobacterium leprae.</p>
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