01962nas a2200325   4500000000100000008004100001260001200042653002400054653002700078653004000105653002200145653002700167100001500194700001600209700001300225700001400238700001300252700001100265700001500276700001100291700001100302700001400313700001500327245010000342856006700442300000800509490000700517520109800524022001401622       2023                            d  bMDPI AG10aInfectious Diseases10aMicrobiology (medical)10aGeneral Immunology and Microbiology10aMolecular Biology10aImmunology and Allergy1 aBeltrame A1 aFargnoli MC1 aAvanzi C1 aSollima L1 aPomari E1 aMori A1 aLongoni SS1 aMoro L1 aOrza P1 aJackson M1 aPerandin F00aLeprosy in an Adopted Woman Diagnosed by Molecular Tools: A Case Report from a Non-Endemic Area  uhttps://www.mdpi.com/2076-0817/12/2/165/pdf?version=1674199638  a1650 v123 a<p>Coupled with its rarity in non-endemic areas, the clinical heterogeneity of leprosy makes diagnosis very challenging. We report a diagnosis of multibacillary leprosy in a 22-year-old Indian woman, adopted at the age of 10 and living in Italy. The patient presented with painful skin lesions on the face, trunk, and lower and upper extremities, associated with dysesthesia and a motor deficit in her left leg following corticosteroid therapy interruption. Histopathology results from the skin lesions suggested leprosy, but no acid-fast bacilli were identified. Molecular biology in a center specializing in tropical diseases confirmed the diagnosis, allowing prompt and adequate treatment. Genotype analysis allowed the identification of a genotype 1D of M. leprae, facilitating the epidemiological investigation of the plausible infection origin. No resistances to rifampicin, dapsone, or ofloxacin were detected. Leprosy will continue to exist in high-income nations, and the incidence may rise over time due to increasing migration and globalization. CARE guidelines were followed.</p>
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