01577nas a2200169   4500000000100000008004100001260001700042653002100059100001100080700001500091700001300106700001400119245006500133856010400198520109100302022001401393       2023                            d  bCureus, Inc.10aGeneral Medicine1 aPark L1 aWallace CE1 aVasile G1 aBuckley C00aA Case of Lepromatous Leprosy With Erythema Nodosum Leprosum  uhttps://www.cureus.com/articles/132279-a-case-of-lepromatous-leprosy-with-erythema-nodosum-leprosum3 a<p>Erythema nodosum leprosum is an immunologic reaction that occurs in patients with lepromatous leprosy. We present the case of a 23-year-old female with a one-week history of fever and painful erythematous nodules along her upper and lower extremities. The patient had immigrated to the United States from Micronesia, where she was partially treated for leprosy two years prior. Histological examination from a punch biopsy demonstrated noncaseating granulomatous inflammation with numerous bacilli highlighted by the Fite stain. The acid-fast bacilli smear was positive. Given the patient’s clinical, laboratory, and histological findings, a diagnosis of lepromatous leprosy with a type 2 erythema nodosum leprosum reaction was established. Multidrug antibiotic therapy with rifampin, dapsone, minocycline, and prednisone was initiated, following the addition of clofazimine. Early recognition and treatment of leprosy are crucial to preventing chronic and disabling complications, especially in instances of systemic inflammatory responses such as erythema nodosum leprosum.</p>
  a2168-8184