02060nas a2200277   4500000000100000008004100001260002200042653002100064653001200085100001500097700001700112700001600129700001600145700001600161700001200177700001600189700001500205700001400220700001500234700001400249245008200263856007000345300002000415520132200435022002501757       2023                            d  bSAGE Publications10aGeneral Medicine10aSurgery1 aPassos JRD1 aSangaleti CT1 aTrincaus MR1 aPrezotto KH1 aAraújo LDO1 aTechy B1 aBaratieri T1 aLentsck MH1 aTaques GR1 aMoreira RC1 aSilva DCD00aEffects of Citric Acid on the Healing Process of Chronic Wound due to Leprosy  uhttps://journals.sagepub.com/doi/reader/10.1177/15347346221147398  a1534734622114733 a<p>Objective: The aim was to describe the effects of the use of citric acid in the healing process of chronic leprosy wounds. Approach: This is a case series, carried out with 5 people with chronic leprosy wounds, under continuous care in an outpatient center wound care in the center-south region of Brazil. The intervention protocol consisted of topical application of 3% citric acid (ointment), on the wound bed, in a thin layer of approximately 2 mm, on alternate days, and followed up for a total period of 8 weeks and secondary coverage rayon and gauze. The cases were analyzed regarding wound dimensions, histology and clinical observation. Results: It was observed in all cases better aspect of the wound bed, presence of granulation tissue and decrease of the inflammatory process with predominance of lymphocytes, reduction of bacterial colonies, increase and verticalization of type I collagen fibers, reduction of type III collagen and increased areas of epithelialization. Innovation: There was also a reduction in the level of pain and exudation after the treatment protocol. Conclusions: Therefore, the use of citric acid in leprosy neuropathic wounds is promising and may be a treatment option, considering its cost, clinical management and possible effect on the chronic inflammatory process.</p>
  a1534-7346, 1552-6941