01505nas a2200205   4500000000100000008004100001260001000042653001900052100001800071700002500089700002500114700002100139700001600160245008000176856009800256300001200354490000700366520091200373022001401285       2022                            d  bLepra10aGeneral Energy1 ados Santos DF1 aHerlys Gomes Braga V1 aJunqueira Oliveira T1 aSabião Borges I1 aGoulart IMB00aGuillain-Barré syndrome following a Type 2 leprosy reaction: A case report  uhttps://leprosyreview.org/admin/public/api/lepra/website/getDownload/63947035afaac164c048cb66  a420-4230 v933 a<p>A 39-years-old male patient with previously treated borderline lepromatous (BL) leprosy, presented with paresthesia and dysesthesia in the feet and hands, associated with fever, arthralgia, and erythema nodosum during a Type-2 leprosy reaction (LR) episode. This evolved in 3 days to a flaccid tetraparesis with areflexia, with gait impairment, in addition to clinical signs of dysautonomia, such as tachycardia, tachydyspnea, and cranial nerve involvement. The nerve conduction study was compatible with an acute inflammatory demyelinating polyradiculoneuropathy and the cerebrospinal fluid (CSF) analysis confirmed an inflammatory pattern. The patient was treated with intravenous immunoglobulin, showing an important clinical improvement. This case describes the unusual association between leprosy and Guillain-Barré syndrome (GBS), emphasizing the importance of recognition of this condition.</p>
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