01351nas a2200265   4500000000100000008004100001260001700042653001700059653001200076653002600088653001100114653002100125653000900146653001200155653000900167653001500176653002500191100001500216700001200231245015500243300001000398490000700408520065600415022001401071       1989                            d  c1989 Oct-Dec10a4-Quinolones10aAnimals10aAnti-Infective Agents10aFemale10aFluoroquinolones10aFoot10aleprosy10aMice10aMice, Nude10aMycobacterium leprae1 aTsutsumi S1 aGidoh M00aStudies on the development of novel anti-leprous chemotherapeutics using nude mice with special reference to a new quinolone carboxylic acid, AT-4140.  a250-80 v583 a<p>In order to develop a novel drug for antileprosy chemotherapy, the inhibitory effects of three synthesized compounds, a supplied antituberculous one and three quinolone carboxylic acids were examined on the growth of leprosy bacilli inoculated into the footpads of nude mice. Amongst them, a new quinolone carboxylic acid, AT-4140 whose chemical structure was 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(cis-3, 5-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid strongly inhibited the growth of leprosy bacilli at doses of 15 and 30 mg/kg. Whereas, the effect of Ofloxacin used as a positive control was limited at the same doses.</p>  a0386-3980