00814nas a2200121   4500000000100000008004100001100001400042700001600056245005500072300001200127490000700139520054600146       2022                            d1 aButlin CR1 aMaghanoy AA00aVentajas de administrar dosis altas de clofazimina  a427-4320 v923 a<p>Besides its role in multidrug therapy, clofazimine at higher doses is widely used for relief of Type 2 (ENL) reaction in leprosy. There is a lack of evidence from clinical trials regarding indications, optimum regimen and risk/benefit ratio to support published guidelines on its use as an anti-reaction drug. Clinical experience suggests that in adults it is safe at high doses (up to 300 mg/day) for limited periods of time but caution is needed with patients of low body weight and in those taking other drugs which may interact.</p>