01911nas a2200193   4500000000100000008004100001260003400042653001400076653002000090100001300110700001100123700001300134700001300147245009400160856010900254300001400363520131500377022002501692       2022                            d  bUniversidad Tecnica de Manabi10aEducation10aGeneral Nursing1 aShukla R1 aSeth D1 aShukla A1 aShukla S00aTransmission features of Mycobacterium leprae throughout the decline of leprosy incidence  uhttps://media.neliti.com/media/publications/430808-transmission-features-of-mycobacterium-l-da523350.pdf  a7973-79823 a<p>Background: Mycobacterium leprae causes leprosy, an infectious disease. As the incidence of the disease declines, the characteristics of new cases begin to diverge from those seen in highly endemic locations, offering potentially valuable insights into ongoing transmission sources. We wanted to see if undiagnosed and untreated new leprosy cases in the community drive transmission more than incompletely treated or relapsing cases. Principle findings/methodology: In January of 2020, a literature search of major electronic databases yielded 134 articles out of 4318 total entries found (PROSPERO ID: CRD42020178923). We presented quantitative data from leprosy case records, along with supporting evidence, to describe the drop in incidence in a variety of settings. The major measures used by countries that achieved a significant reduction in incidence included BCG vaccination, active case detection, adherence to combination therapy, and continuous surveillance after treatment. In a study of 3950 leprosy case data from 22 low-endemic nations, 48.3% were thought to be imported, beginning from transmission outside the country. With 122 cases of suspected relapse from earlier leprosy treatment, the majority of cases (64.4%) were multibacillary and frequently verified with skin biopsy.&nbsp;</p>
  a2550-696X, 2550-6978