01646nas a2200337   4500000000100000008004100001260001600042653002600058653001300084653002400097653002000121653004100141653003100182653001100213653001200224653001800236653003100254653001500285100001800300700001300318700002100331700001600352700001100368700001400379700001700393245014400410300001000554490000600564520072400570022001401294       1986                            d  c1986 Aug 0910aArthritis, Rheumatoid10aEpitopes10aGenes, MHC Class II10aHLA-DR4 Antigen10aHistocompatibility Antigens Class II10aHistocompatibility Testing10aHumans10aleprosy10aMycobacterium10aMycobacterium tuberculosis10aSkin Tests1 aOttenhoff T H1 aTorres P1 aDe Las Aguas J T1 aFernandez R1 aEden W1 aVries R R1 aStanford J L00aEvidence for an HLA-DR4-associated immune-response gene for Mycobacterium tuberculosis. A clue to the pathogenesis of rheumatoid arthritis?  a310-30 v23 a<p>Antigens of Mycobacterium tuberculosis, M leprae, M scrofulaceum, and M vaccae were injected intradermally in 86 caucasoid leprosy patients, and skin responses (measured in mm of induration at 72 h) were analysed in relation to HLA class II phenotypes. HLA-DR4 was associated with high responsiveness to antigens specific to M tuberculosis but not to antigens shared with other mycobacteria (p = 0.0005). Because DR4 is associated with rheumatoid arthritis (RA) and because a role for M tuberculosis antigens has been suggested both in experimentally induced autoimmune arthritis in rats and in RA, the DR4 associated regulation of the immune response to M tuberculosis may be relevant to the pathogenesis of RA.</p>  a0140-6736