01265nas a2200289   4500000000100000008004100001260001300042653001200055653002400067653004400091653002000135653003000155653001300185653000900198653002300207653002500230653001400255653001800269653002900287100001600316700001700332245009400349300001100443490000700454520050000461022001400961       1988                            d  c1988 Jun10aAnimals10aAntigens, Bacterial10aAntigens, Differentiation, T-Lymphocyte10aCells, Cultured10aCytotoxicity, Immunologic10aEpitopes10aMice10aMice, Inbred C57BL10aMycobacterium leprae10aPhenotype10aSchwann Cells10aT-Lymphocytes, Cytotoxic1 aSteinhoff U1 aKaufmann S H00aSpecific lysis by CD8+ T cells of Schwann cells expressing Mycobacterium leprae antigens.  a969-720 v183 a<p>In vitro cultured murine Schwann cells which were devoid of class I and class II gene products of the major histocompatibility complex expressed class I, though not class II, antigens after stimulation with recombinant interferon-gamma. Recombinant IFN-gamma-stimulated Schwann cells after priming with M. leprae were lysed by antigen-specific CD8+ T lymphocytes in vitro. These findings suggest that specific lysis of M. leprae-infected Schwann cells by CD8+ CTL plays a role in leprosy.</p>  a0014-2980