02135nas a2200301   4500000000100000008004100001260001200042653002400054653002700078653002200105653002900127653001900156100001600175700002200191700001200213700001400225700002300239700001900262700002200281700001300303700002000316700002300336700002300359700001400382245010900396520131400505022001401819       2022                            d  c04/202210aAnxiolytic behavior10aCentral Nervous System10aChronic infection10aDepression-like behavior10aMurine leprosy1 a-Regalado P1 aSalazar-Juárez A1 aOscar R1 ade Oca CA1 aHurtado-Alvarado G1 aArce-Paredes P1 aPérez-Sánchez G1 aPavón L1 aGirón-Pérez M1 aHernández-Pando R1 aAlvarez-Sánchez M1 aEnrique B00aDevelopment of anxiolytic and depression-like behavior in mice infected with mycobacterium lepraemurium.3 a<p>Murine leprosy is a systemic infectious disease of mice caused by Mycobacterium lepraemurium (MLM) in which the central nervous system (CNS) is not infected; nevertheless, diseased animals show measurable cognitive alterations. For this reason, in this study, we explored the neurobehavioral changes in mice chronically infected with MLM. BALB/c mice were infected with MLM, and 120 days later, the alterations in mice were evaluated based on immunologic, histologic, endocrine, neurochemical, and behavioral traits. We found increases in the levels of IL-4 and IL-10 associated with high bacillary loads. We also found increase in the serum levels of corticosterone, epinephrine, and norepinephrine in the adrenal gland, suggesting neuroendocrine deregulation. Mice exhibited depression-like behavior in the tail suspension and forced swimming tests and anxiolytic behavior in the open field and elevated plus maze tests. The neurobehavioral alterations of mice were correlated with the histologic damage in the prefrontal cortex, ventral hippocampus, and amygdala, as well as with a blood-brain barrier disruption in the hippocampus. These results reveal an interrelated response of the neuroimmune-endocrinological axis in unresolved chronic infections that result in neurocognitive deterioration.</p>
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