01656nas a2200289   4500000000100000008004100001260001200042653002200054653001500076653001400091653001600105653003100121653002000152100000900172700001200181700001200193700001200205700001000217700001000227700001100237245010200248856008100350300001100431490000700442520090300449022001401352       2021                            d  c01/202110aEpithelioid Cells10aFoam Cells10aGranuloma10aMacrophages10amultinucleated giant cells10amycobacteriosis1 aGe G1 aJiang H1 aXiong J1 aZhang W1 aShi Y1 aTao C1 aWang H00aProgress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660122/pdf/fimmu-12-752657.pdf  a7526570 v123 a<p>Mycobacteriosis, mostly resulting from (MTb), nontuberculous mycobacteria (NTM), and (), is the long-standing granulomatous disease that ravages several organs including skin, lung, and peripheral nerves, and it has a spectrum of clinical-pathologic features based on the interaction of bacilli and host immune response. Histiocytes in infectious granulomas mainly consist of infected and uninfected macrophages (Mφs), multinucleated giant cells (MGCs), epithelioid cells (ECs), and foam cells (FCs), which are commonly discovered in lesions in patients with mycobacteriosis. Granuloma Mφ polarization or reprogramming is the crucial appearance of the host immune response to pathogen aggression, which gets a command of endocellular microbe persistence. Herein, we recapitulate the current gaps and challenges during Mφ polarization and the different subpopulations of mycobacteriosis.</p>
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