01514nas a2200301   4500000000100000008004100001260001700042653001500059653001000074653001200084653003000096653001100126653001100137653001200148653000900160653001300169653000900182100001200191700001200203700001600215700001400231245008300245300001100328490000700339050003200346520082000378022001401198       1990                            d  c1990 Jan-Mar10aAdolescent10aAdult10aDapsone10aDrug Therapy, Combination10aFemale10aHumans10aleprosy10aMale10aRifampin10aSkin1 aKar P K1 aJha P K1 aPanaych J S1 aSnehi P S00aClinico-histopathological study of multidrug therapy in indeterminate leprosy.  a98-1030 v62  aInfolep Library - available3 a<p>A study was undertaken in 42 patients with indeterminate leprosy to evaluate the efficacy of multidrug therapy (MDT) in Indeterminate leprosy for 12 months. The main clinical finding was a single hypopigmented macule in 31 (73.8%) of the 42 cases. Histopathologically all cases showed lymphohistiocytic infiltration around skin appendages and dermal nerves. At the end of six months of MDT all the cases were evaluated clinically and 33 (85.5%) showed marked improvement or total inactivation while the lesions were still active clinically in 21.4% cases. Histopathological examination of lesions in 30 patients showed complete histological resolution in 9 cases only. At the end of one year of treatment it was found that 28 cases (66.3%) had become inactive and only 2 (4.7%) were found to be still active.</p>  a0254-9395