02338nas a2200205   4500000000100000008004100001260005300042100001500095700001900110700001300129700001800142700001300160700001700173700001300190700001400203700002900217245017400246856005900420520165300479       2018                            d  bSCITEPRESS - Science and Technology Publications1 aPratiwi KD1 aTrisniartami .1 aAlinda M1 aKusumaputra B1 aAstari L1 aListiawan MY1 aAgusni I1 aRantam FA1 aRosita Sigit Prakoeswa C00aA Case Report: The Efficacy of Human Amniotic Membrane Mesenchymal Stem Cells-Conditioned Medium (hAMMSC-CM) for Treating Plantar Pedis Trophic Ulcer in Leprosy Patients  uhttps://www.scitepress.org/Papers/2018/81593/81593.pdf3 aLeprosy is an endemic disease in many countries with consequences of neuropathy that may leads to plantar
trophic ulcer. The management of trophic ulcers is difficult due to its recurrent and recalcitrant
characteristics. Placental derived cells are known to release factors with potential immunomodulatory and
trophic activities. In this study we use the human amniotic membrane mesenchymal stem cells-conditioned
medium (hAMMSC-CM) gel to promote the wound healing of trophic ulcer. A-50-years-old female
presented with a trophic ulcer over the sole of her right foot since 3 years ago. The patient gave a history of
decreased sensation over the right foot and was a known case of lepromatous leprosy released from
treatment 2 years back after completing multibacillary multi-drug therapy for 1 years. Cutaneous
examination revealed a single non-healing ulcer over the plantar aspect of the right foot with pale
granulation tissue and seropurulent discharge at the base. Touch and pain sensation were lost over the foot
and up to the lower leg one-third of the leg. The result of microbiology Mycobacterium leprosy examination
was bacterial index (BI) 0 and morphological index (MI) was negative. A diagnosis of plantar pedis trophic
ulcer in a treated case of leprosy was made. The ulcer managed by given topical hAMMSC-CM gel and
covered with transparent film dressings. Application of gel was done every 3 days, and weekly evaluation
included measurement of the size and the depth of the ulcer was done. The patient was treated with
hAMMSC-CM for 8 weeks. The ulcer was significantly resolved, but there was no complete healing.