01557nas a2200217   4500000000100000008004100001260001300042653001100055653001800066653001100084653001200095653000900107100001300116700001600129700001500145245005300160300001100213490000700224520109400231022001401325       1990                            d  c1990 Mar10aFemale10aGlucuronidase10aHumans10aleprosy10aMale1 aGeorge J1 aRajendran M1 aBhatia V N00aSerum beta-glucuronidase in subtypes of leprosy.  a106-100 v913 a<p>Serum beta-glucuronidase activity was estimated using phenolphthalein mono-beta-glucuronic acid as substrate in 176 individuals including 72 lepromatous leprosy patients, 24 patients of borderline leprosy, 42 of borderline tuberculoid and 38 healthy controls. Of these, 35 patients (20 with lepromatous leprosy, 5 with borderline leprosy and 10 with borderline tuberculoid) were untreated. The enzyme levels were increased significantly in all types of leprosy, the highest levels being seen in treated lepromatous leprosy patients (105.0 SU). There was also a significant difference in the enzyme activity between untreated patients and those on combined dapsone and rifampicin therapy, in all three types of leprosy. Among untreated patients, the maximum value observed in lepromatous leprosy was 93.4 SU. The lowest enzyme level in healthy control was 19.5 SU and the maximum was 54.0 SU. The results suggest that in leprosy patients, especially in those on daily multidrug regimens, there is an extensive damage of leucocytes and liver cells where the enzyme is largely present.</p>  a0971-5916