01523nas a2200301   4500000000100000008004100001260001300042653001500055653002300070653001000093653002100103653001800124653001100142653002300153653001100176653001200187653002000199653001600219100001500235700001500250700001600265245006300281300001100344490000700355050001500362520083000377022001401207       1990                            d  c1990 Jun10aAdolescent10aAntibody Formation10aChild10aChild, Preschool10aComplement C310aHumans10aImmunity, Cellular10aInfant10aleprosy10aLeukocyte Count10aLymphocytes1 aSehgal V N1 aSharma V K1 aPrakash S K00aCell-mediated and humoral immunity in leprosy in children.  a356-610 v17  aSEHGAL19903 a<p>Cell-mediated and humoral immunity were studied in 25 children between 0 and 14 years with leprosy. Cell-mediated immunity was studied in vivo by lepromin and epicutaneous sensitization with dinitrochlorobenzene (DNCB) and T-lymphocytes and their subpopulations (T4 and T8) in the peripheral blood. Humoral immunity was evaluated by B-lymphocyte count and immunoglobulins (IgG, IgM and IgA). Along with complement, component C3 was also measured in the serum. Lepromin (Mitsuda) and DNCB responses were significantly poor in mid-borderline (BB) leprosy. The hematological profile, including T-lymphocytes, their subpopulations, B-lymphocytes, serum immunoglobulins, and C3, were found to be normal in all forms of leprosy. The relatively short duration of disease and the low bacterial load may explain these findings.</p>  a0385-2407