02143nas a2200337 4500000000100000008004100001260002300042653002300065653001700088100001100105700001100116700001200127700001000139700001200149700001200161700001000173700001100183700001000194700001000204700000900214700001100223700000900234700000900243700001100252245010900263856005500372300001200427490001400439520133800453022001401791 2021 d bInforma UK Limited 10 aMolecular Medicine 10 aPharmacology 1 aLong S 1 aWang L 1 aJiang H 1 aShi Y 1 aZhang W 1 aXiong J 1 aSun P 1 aChen Y 1 aMei Y 1 aPan C 1 aGe G 1 aWang Z 1 aWu Z 1 aYu M 1 aWang H 00 aSingle-Nucleotide Polymorphisms Related to Leprosy Risk and Clinical Phenotypes Among Chinese Population uhttps://www.dovepress.com/getfile.php?fileID=71553 a813-821 0 vVolume 14 3 aBackground: Genome-wide association studies (GWASs) have identified some immune-related single-nucleotide polymorphisms (SNPs) to be associated with leprosy.
Methods: This study investigated the association of 17 SNPs based on previously published GWAS studies with susceptibility to leprosy, different polar forms and immune states of leprosy in a case–control study from southwestern China, including 1344 leprosy patients and 2732 household contacts (HHCs) (1908 relatives and 824 genetically unrelated contact individuals). The differences of allele distributions were analyzed using chi-squared analysis and logistic regression.
Results: After adjusting covariate factors, rs780668 and rs3764147 polymorphisms influenced susceptibilities to genetically related or unrelated leprosy contact individuals. rs142179458 was associated with onset early cases, rs73058713 A allele and rs3764147 A allele increased the risk of reversal reaction, while rs3764147 G allele had higher risk to present lepromatous leprosy and erythema nodosum leprosum.
Conclusion: Our results demonstrated that genetic variants in the LACC1, HIF1A, SLC29A3 and CDH18 genes were positively correlated with the occurrence of leprosy and leprosy clinical phenotypes, providing new insights into the immunogenetics of the disease. a1178-7066