01115nas a2200289   4500000000100000008004100001260001300042653001200055653001200067653003100079653001100110653001200121653000900133653002100142653002500163653001600188100001500204700001600219700001600235700001300251245006000264856004100324300001100365490000700376520042800383022001400811       1981                            d  c1981 Dec10aAnimals10aDapsone10aDrug Resistance, Microbial10aHumans10aleprosy10aMice10aMice, Inbred CBA10aMycobacterium leprae10aPhilippines1 aGuinto R S1 aCellona R V1 aFajardo T T1 aCruz E C00aPrimary dapsone-resistant leprosy in Cebu, Philippines.  uhttp://ila.ilsl.br/pdfs/v49n4a07.pdf  a427-300 v493 a<p>A survey of the prevalence of primary dapsone-resistant leprosy in Cebu, Philippines, has yielded an estimate of 3.6 per 100. Fifty-three of 55 patients proved to have M. leprae fully susceptible to dapsone. The organisms of two patients multiplied in mice administered the minimal effective dose of dapsone; and those of one of these patients also multiplied in mice administered dapsone in a 10-fold larger dose.</p>
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