01525nas a2200325   4500000000100000008004100001260001600042653001000058653002600068653003200094653002900126653002900155653001100184653001100195653001200206653000900218653001600227653002700243653001600270653001200286653001700298100001300315700001500328700001900343245008000362300001100442490000800453520072400461022001401185       1979                            d  c1979 Aug 0310aAdult10aClinical Enzyme Tests10aEvaluation Studies as Topic10aFalse Negative Reactions10aFalse Positive Reactions10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aPeptidyl-Dipeptidase A10aSarcoidosis10aSarcoma10aTuberculosis1 aShultz T1 aMiller W C1 aBedrossian C W00aClinical application of measurement of angiotensin-converting enzyme level.  a439-410 v2423 a<p>Assay of angiotensin-converting enzyme (ACE) in the sera of 69 patients demonstrated elevated levels in 19 of 22 (86%) of those with clinically active, biopsy-proved sarcoidosis. Patients with dormant sarcoidosis and generally those with various other disorders had normal levels. Elevated levels were also seen in six cases possibly representing sarcoid variants and in one case each of leprosy, carcinoma, tuberculosis, lymphomatoid granulomatosis, and immunoblastic sarcoma. Although ACE is sensitive to active sarcoidosis, the presence of false-positive findings limits its diagnostic usefulness to an adjunctive role; the assay should be combined with medical evaluation and tissue biopsy in selected cases.</p>  a0098-7484