01492nas a2200313   4500000000100000008004100001260000900042653001200051653001800063653002000081653002700101653002300128653003700151653001200188653001600200653000900216653002500225653002200250653001700272100002300289700001800312700001400330700001800344245011800362300001000480490000700490520066700497022001401164       1990                            d  c199010aAnimals10aCell Division10aChronic Disease10aDisease Models, Animal10aHistocytochemistry10aImmunologic Deficiency Syndromes10aleprosy10aMacrophages10aMice10aMycobacterium leprae10aPeritoneal Cavity10aTime Factors1 aVishnevetskiĭ F E1 aFreĭdlin I S1 aIushin IM1 aUrliapova N G00a[The modelling of chronic infection (experimental leprosy) against a background of macrophagal immunodeficiency].  a46-500 v523 a<p>The dynamics of mycobacterial multiplication was followed in mice with intraplantar leprosy infection and preinduced macrophage insufficiency. The characteristics of Shepard's model appeared to be similar to those of the method proposed by the authors including the susceptibility to the main antileprosy drugs. Peritoneal macrophages were cytochemically studied in the process of development of mononuclear phagocyte deficiency and experimental leprosy. It was concluded that the method proposed preserving all the merits of Shepard's model should allow one to shorten significantly the duration of testing potential drugs for their antileprosy activity.</p>  a0004-1955