01495nas a2200169   4500000000100000008004100001260001200042100001200054700001700066700001500083245009300098856007300191300001400264490000700278520102600285022001401311       2021                            d  c01/20211 aBasso M1 ade Andrade R1 ada Silva R00aTrend of epidemiological indicators of leprosy in an endemic state of the Amazon region.  uhttps://www.scielo.br/pdf/rgenf/v42/1983-1447-rgenf-42-e20190520.pdf  ae201905200 v423 a<p><b>OBJECTIVE: </b>To characterize the temporal trend of epidemiological indicators of leprosy in the State of Amapá.</p><p><b>METHOD: </b>Time series study, carried out in the Notifiable Diseases Information System. The indicators analyzed were: annual detection rate of new cases, detection rate of new cases in the population from 0 to 14 years old, rate of new cases with grade 2 of disability, proportion of new cases with grade 2 and proportion of new multibacillary cases, between 2005 and 2018. The analysis of the temporal evolution was made by linear regression.</p><p><b>RESULTS: </b>The detection rate of new cases and the rate of children under 15 years showed a decreasing trend. The rate of new cases with grade 2 of disability and the proportion of cases with grade 2 showed oscillation. The proportions of multibacillary remained constant.</p><p><b>CONCLUSION: </b>The epidemiological indicators analyzed suggest active transmission and late diagnosis, signaling a possible hidden endemic disease.</p>  a1983-1447