02102nas a2200241 4500000000100000008004100001260001600042653002500058653001400083653002300097100001200120700001300132700001200145700001400157700001400171700001400185700001500199700001400214245014000228856007200368520140600440022001401846 2021 d bElsevier BV 10 aPhysiology (medical) 10 aNeurology 10 aClinical Neurology 1 aAkita J 1 aMiller L 1 aMello F 1 aBarreto J 1 aMoreira A 1 aSalgado M 1 aKirchner D 1 aGarbino J 00 aComparison between nerve conduction study and high-resolution ultrasonography with color doppler in type 1 and type 2 Leprosy reactions uhttps://www.sciencedirect.com/science/article/pii/S2467981X21000081 3 aObjective
To analyze the role of high-resolution ultrasonography with color Doppler (HRUS with CD) to diagnose inflammatory activity (IA) in nerves of leprosy patients under type 1 (RT1) and 2 (RT2) reactions compared to Nerve Conduction Studies (NCS).
Methods
Leprosy patients with signs or symptoms suggestive of neuritis (RT1 and RT2) without corticosteroids use were selected. They were evaluated by NCS and subsequently by HRUS with CD. Subacute segmental demyelination and the presence of blood flow, respectively, were considered signs of IA. The two methods were compared for their ability to diagnose patients with leprosy reactions.
Results
A total of 257 nerves from 35 patients were evaluated. NCS and HRUS with CD diagnosed IA in 68% and 74% of patients, respectively. When both methods were used concomitantly, the diagnosis rate was 91.4%. HRUS with CD was particular helpful when there was minimal neurophysiological compromise in NCS or when motor potentials were not detected.
Conclusion
HRUS with CD was able to detect leprosy reactions, especially when combined with NCS. It was especially useful in two opposite situations: nerves with only minor changes and those without motor response in NCS.
Significance
Our data shows the usefulness of HRUS and CD, similar to NCS, as a tool to diagnose leprosy reactions. a2467-981X