01315nas a2200181   4500000000100000008004100001260001200042653001600054653002200070653000900092653001600101653002100117653001900138100001200157245007400169520087600243022001401119       2021                            d  c03/202110a
M. leprae
10a
M. lepromatosis
10aNOS210aclofazimine10ainterferon-gamma10ainterleukin-171 aAdams L00aSusceptibility and resistance in leprosy: Studies in the mouse model.3 a<p>Leprosy is a chronic granulomatous infectious disease caused by the pathogen, Mycobacteriu M. lepromatosis, and the more recently discovered, M. lepromatosis. Described in 1873, M. leprae was among the first microorganisms to be proposed as a cause of a human infectious disease. As an obligate intracellular bacterium, it has still not thus far been reproducibly cultivated in axenic medium or cell cultures. Shepard's mouse footpad assay, therefore, was truly a breakthrough in leprosy research. The generation of immunosuppressed and genetically engineered mice, along with advances in molecular and cellular techniques, has since offered more tools for the study of the M. leprae-induced granuloma. While far from perfect, these new mouse models have provided insights into the immunoregulatory mechanisms responsible for the spectrum of this complex disease.</p>  a1600-065X